Tissue necrosis from im injection

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May 18, · [Aseptic tissue necrosis: a severe complication after intramuscular injections]. [Article in German] Müller-Vahl H. Aseptic necrosis after intramuscular injection (Nicolau syndrome) occurred in 38 patients. Symptoms were severe immediate pain, swelling and livid discoloration of the skin with development of gangrene of skin and muscle peermade.info by: 9.

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Nicolau syndrome (NS) is a rare complication of an intramuscular injection characterized by severe pain, skin discoloration, and varying levels of tissue necrosis.

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Intramuscular injections tend to have a faster absorption rate, depending on factors such as age, activity levels, and the particular muscle chosen. such as seizures, cardiac arrhythmias, tissue necrosis, death. Which is why injection sites are usually chosen to minimise the risk of accidentally hitting a major vessel or nerve.


Alternating the injection site can prevent complications from tissue necrosis. Repeated injection of any medication into the same area will increase the size of the necrotic lesion.[3,4] Conclusion Utilizing the proper technique when giving an IM injection will help minimize the possibility of a complication. Tissue necrosis is a rare but serious complication of intramuscular administration of medicines, including nonsteroidal antiinflammatory drugs (NSAIDs). Pain often occurs at the time of the injection, but tissue necrosis typically becomes apparent a few days peermade.info by:
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In the report by Pillans2, there were 3 reports of extensive tissue necrosis. In one of these cases, Streptococcus epidermidis was grown and in another case, the patient was an obese psychiatric patient who had received numerous previous intramuscular injections and Author: Desmond P O'Sullivan, Janine Collins.

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Microbes entering the body by injection cause dangerous infections and abscesses. In addition to sepsis, the spread of bacteria, if left untreated, may result in a rare but life-threatening soft tissue inflammation which is necrotizing i.e. leads to necrosis. Bacteria causes a . The importance of good injection technique cannot be understated. It should not be forgotten that among potential complications of IM injection are abscess, cellulites, tissue necrosis, granuloma, muscle fibrosis, contractures, haematoma and injury to blood vessels, bones and peripheral nerves.

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Intramuscular (IM) injection: A method of administering medication directly into muscle tissue (Macqueen et al ). Subcutaneous (SC) injection: Delivers medication below epidermis and dermis layers into SC tissue (Ford et al ) Applicable to These guidelines are applicable to nurses who administer medications by injection to children. Tissue necrosis is a rare complication of intramuscular drug injection and may involve the skin, subcutaneous tissue and muscular layer. The pathogenesis of the necrotic process is Cited by: 7.

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